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Under these conditions, the stimulatory effect of activating the OB GLP-1R pathway on insulin secretion and the consequent improvement in glucose tolerance were abolished in WD mice (Fig

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The abstract is also published online in the Abstracts in Journal - ObesityWeek

Given that obesity is a chronic and relapsing disease, it is important to understand the effectiveness of different strategies to maintain WL: TRIUMPH-6 (NCT06859268) will assess changes in bodyweight at 116 weeks in individuals with obesity who have completed 80 weeks of retatrutide, comparing continued treatment at high or low doses of retatrutide versus switching to placebo for the last 36 weeks