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Therefore, it would be of interest to investigate whether similar molecular mechanisms involving promiscuous disease-specific intracellular aggregation underlie these disorders as well

Support patient behavior change

NICE has issued guidance supporting the use of semaglutide (Wegovy) for chronic weight management in adults meeting specific clinical criteria (NICE TA814), and tirzepatide (Mounjaro) for managing overweight and obesity, as well as for the treatment of type 2 diabetes (NICE TA875)

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Parallel fibrogenesis in the liver and myocardium adds to ventricular stiffness and diastolic dysfunction, while gut dysbiosis from a Western diet heightens systemic inflammation and endotoxemia, worsening cardiac and hepatic dysfunction