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Acta BioMed
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Inclusion/exclusion criteria: The criteria for inclusion are quite standard for clinical trials in this field: The exclusion criteria: The criteria chosen are appropriate to minimize confounding variables and safety risks while providing a clear POC for efficacy and safety in a typical population of patients with obesity and at higher risk of T2DM
This results in directing APS into cysteine, methionine and glutathione synthesis and away from synthesis of PAPS
The hypomethylation agent bisdemethoxycurcumin acts on the WIF-1 promoter, inhibits the canonical wnt pathway and induces apoptosis in human non-small-cell lung cancer
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