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For analysis of intact cells, HepG2 (10 7 /ml in DMEM medium w/o serum and antibiotics) were treated with NFT (5 mM)

The theoretical thyroid cancer risk based on rodent studies has not materialized in human populations after over a decade of clinical use, though ongoing pharmacovigilance continues

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The peptide affects sphingomyelin pathway transmission of cytokine signals, influencing both stress response mechanisms and immune-competent cell function during metabolic challenges

Gastroenterological referral and further investigations such as colonoscopy may be warranted to establish an accurate diagnosis if inflammatory markers are elevated or symptoms persist