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Exercises like squats, deadlifts, lunges, leg presses, and overhead presses create the mechanical loading that stimulates bone formation and preserves muscle mass during weight loss

doi: 10.1016/j.tips.2020.06.009

This reframes the entire comparison: the relevant question is rarely how much weight can a drug take off in a year but how much can be kept off over a decade of continued, tolerable therapy. On that longer horizon, tirzepatide has actual data and retatrutide has, so far, only a promising short-to-medium-term trajectory

One or more illustrative embodiments have been described by way of example

Thyroid 34 (4), 403418