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Future perspectives and research gaps While the promise of PGPR is immense, a persistent translational gap remains between laboratory efficacy and consistent field-scale performance
Specifically, liraglutide reduced lipid peroxidation (LPO) levels, increased reduced glutathione levels and enhanced SOD activity in a mouse model of acute liver injury, thereby reducing oxidative stress (121)
In particular, the mitochondrial inner membrane is impermeable to fatty acyl-CoA thioesters and, thus, the specialized CS, for transporting fatty acids across mitochondrial membranes has evolved 18
6/27/2025 Isabelle B
The former is likely attributable to the competing multimorbid status in the generally higher risk population with T2DM, that can attenuate the overall beneficial effects of GLP-1RA
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