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Yes, some individuals may experience nausea, diarrhoea, abdominal discomfort, or vomiting during treatment

Due to its roles in such a broad array of systems, targeting the ghrelin receptor with agonists or antagonists will not only affect the phenomenon of interest, such as feeding, but will also affect the other systems in which ghrelin is involved, leading to unwanted side effects

Ipamorelin is a short-acting secretagogue targeting stomach ghrelin release without increasing appetite, lasting only hours

Those experiencing significant GI side effects should first discuss dosage adjustment and standard management strategies with their prescribing provider

Step 3: Support with High-Bioavailability Supplements