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Initiating estrogen therapy earlier in the menopausal transition, typically within 10 years of the final menstrual period and before age 60, is associated with a more favorable cardiovascular profile [26]

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The - glutamyl amino acids or oxoproline could be signaling molecules to activate the transport of amino acids through membranes

Furthermore, extensive research suggests that OS may impact cognitive function through various pathways, such as directly damaging parvalbumin-expressing interneurons (PVIs) (Schiavone et al., 2009), hindering oligodendrocyte precursor cell (OPC) proliferation and myelin formation in the prefrontal cortex (PFC) (Maas et al., 2021), disrupting the bloodbrain barrier (BBB) (Geng et al., 2023), and inducing mitochondrial dysfunction (Fizikova et al., 2023)

2 One of the key features of PCOS is hyperandrogenism, which refers to elevated levels of androgens like testosterone