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In recent years, two classes of glucose-lowering medications,sodium-glucose cotransporter 2 inhibitors (SGLT2-I) and glucagon-like peptide-1 receptor agonists (GLP-1RA),have emerged as cornerstone therapies due to their robust cardiovascular and renal protective effects

The scientists then used directed evolution, a laboratory process that generates and selects improved enzyme variants

This reveals which subpopulations in new indications are most likely to be responsive to GLP-1s and which are not, and which have the highest likelihood of specific adverse events

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Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation