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Start at 250 mcg Before Increasing If you plan to use 500 mcg daily, start at 250 mcg for the first 5-7 days

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McGraw-Hill / Lange rxlist.com (Amaryl ) rxlist.com (Glucotrol ) rxlist.com (DiaBeta ) Keywords Glitinides Repaglinide Trade Name: Prandin Drug Class: oral hypoglycemic, insulin secretagogue, meglitinide, glinide Mechanism of Action: Similar to sulfonylureas - inhibits potassium efflux (blocks ATP-regulated K channels), causing depolarization & insulin release from pancreatic -cells (see Figure 1 in Beta Cell Pharmacology) has a weaker binding affinity and faster dissociation from the SUR1 binding site compared to sulfonylureas Stimulates a transient release of insulin from pancreatic beta cells that, when administered with a meal, is useful for controlling postprandial hyperglycemia associated with Type 2 diabetes (see Figure 2 in Beta Cell Pharmacology)

According to guidance from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), prescription weight management medications are generally intended for adults with obesity or overweight who have weight-related medical problems