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Both ATF4 and ATF3 bind to these elements, with ATF4 binding primarily to the ATF/CRE site and the ACM site, especially under stress conditions, while ATF3 binds to the ATF/CRE site in both basal and stress conditions

It is understood to be caused by dysregulation of the complement system, leading to abnormal deposition of complement protein C3 in the kidneys glomeruli

Alexander Fleming, Helene Hanaire, Reinhard W

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31 Less commonly, hyperthyroidism is caused by conditions other than Graves disease, including toxic multinodular goiter, in which non-cancerous growths in the thyroid cause the gland to swell and make too much T4