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These new findings encourage a novel working hypothesis for further research, that a chemical-modification mechanism enables transformation of HGF through interaction or reaction with LASSS under physiological conditions, resulting in the retention of HGFs biological activity after exposure to peroxynitrite, at least until an enhanced form of HGF undergoes metabolic turnover in vivo

doi:10.1007/s10238-017-0479-9

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Unlike systemic immunosuppressants, KPV appears to act locally at mucosal surfaces without broad immune dampening

This therapeutic was introduced in the United States in 2012