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Circulation 2008;117:23402350

Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice

Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

Because it delivers the fully formed, intact glutathione molecule directly to the cells, it does not require the body to synthesize it from precursors, and it does not trigger the histamine-liberating effects associated with NAC

these signs require urgent fluid resuscitation and medical care