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Its non-selective receptor profile also allows researchers to study downstream effects associated with MC3R and MC4R signaling pathways

among those, GTPases or their activators/inhibitors (Tiam-1 - T-cell lymphoma invasion and metastasis-inducing protein 1, Rho-C - Ras homolog gene family, member C), and receptor tyrosine kinase (RTK) upstream of Rho GTPases as hepatocyte growth factor receptor (HGFR/c-Met) or tyrosine kinase receptor (Trk-A) [22]

Topical skincare: Vitamin C serums, hyaluronic acid and niacinamide are typically safe for use

PMID: 28497060

All immunofluorescence images were obtained using an LMS700 laser scanning confocal microscope (Zeiss, Oberkochen, Germany), and the images were analyzed using Image-Pro plus 6.0 software (Media Cybernetics, Silver Spring, MD, USA)