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This is less common than nausea or vomiting, and symptoms typically improve within 4-8 weeks as tolerance develops

These molecular differences could explain the slightly different dry mouth profiles between medications

When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)