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It is evident that CNS GLP-1R signaling is essential for mediating the pharmacological action of GLP-1R agonists on energy metabolism as genetic deletion of CNS GLP-1R signaling in mice ablates the action of peripherally administered liraglutide on food intake and body weight reduction (Sisley et al., 2014)

The animals were carefully observed post-intervention for any adverse effects or behavioral changes

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Zhou X, Xu D, Li M, Zeng X

A few commenters also expressed concern that the proposed attestation that the hospital has provided all necessary information available to the hospital for the public to be able to derive the dollar amount risks ensnaring hospitals and health systems in a trap: since hospitals are unable to provide this detailed information, they cannot meet the new requirements of the attestation