What distinguishes the approach is that upstream genetic context
It belongs to a class of drugs known as multi-receptor agonists, and its mechanism of action is notably broad: it simultaneously activates three hormone receptors the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
Interestingly, in trajectory 3 after 750 ns, the dynamic ECD moves back toward the TMD and is stabilized in a conformation that forms contacts mainly with ECL1, resembling the closed ECD conformation in the crystal structure
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