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The 4-PBA group showed mild sinusoidal congestion with focal hepatocyte necrosis as manifested by nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia (Figure 8A), yet it significantly attenuated histopathological scoring compared to MTX-group (Figures 8BD)

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Therapeutic category/Drug classification Semaglutide Injection is a prescription-only injectable medicine

93 Glutamatergic hyperactivity with its ensuing excitotoxicity and oxidative stress are also thought to play a role, making NAC a potential treatment option

When combined with clinical biomarkers (fasting glucose, insulin, HOMA-IR) and provider assessment, genetic insights can support a more informed conversation about whether metformin + semaglutide aligns with your metabolic needs, expected tolerability, and long-term health goals