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When folding stress occurs in the ER, the misfolding of tyrosinase affects its function, thereby inhibiting melanogenesis

IFN- production by amyloid specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimers disease

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The evolutionary gene silence for hepatic uricase in humans and certain primates dampened UA degradation, resulting in higher physiological levels in these upper-order mammals

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