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A blood test will confirm a deficiency, with typical thresholds being total B12 levels under 180 nanograms per litre or active B12 below 25 pmol/l

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However, it is noteworthy that, in critically ill patients treated with ECMO, the presence of a primary disease can also contribute to the development of an inflammatory response in the organism system

This high specificity minimizes off-target drug distribution in healthy tissues, thereby reducing toxicity and adverse effects [347]