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Some weight loss clinics have even included B12 shots into their package deals, with some added associated benefits

Risk factors include underlying renal insufficiency, intravascular volume depletion (sometimes seen in people on strong diuretics, as well as those with poor oral fluid intake, gastroenteritis, or chronic diarrhea), diabetes, heart failure, being 60 years of age or older, exposure to multiple nephrotoxins, etc

This is why toe cramps often occur after strenuous exercise or during hot weather when fluid loss is significant

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