Moreover, key flavonoids such as quercetin (Khursheed et al., 2020) and fisetin (Szymczak and Cielecka-Piontek, 2023) exhibit extremely poor aqueous solubility and high lipophilicity, resulting in limited dispersibility in topical formulations and thereby potentially limiting skin permeation
When applied to skin, it's converted through a two-step enzymatic process - first to retinaldehyde, then to retinoic acid - before it becomes biologically active
Huang C, Mattis P, Perrine K, Brown N, Dhawan V, Eidelberg D
The anti-inflammatory compounds in plant foods may contribute to healthy aging and reduced disease risk
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