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Further, research indicates that quercetin mitigates endoplasmic reticulum stress by promoting Sirt1-mediated deacetylation of Nrf2, NF-B p65, eIF2, and xbp-1 (Wahyu et al., 2022)

TABLE 2 Statistics of gene therapy and RNA interventions to elevate GPX4 or inhibit promoters for OA treatment

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