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Virus injection and cannula implantation Mice were deeply anesthetized with pentobarbital (20 mg/kg, i.p.) and were immobilized on a stereotaxic frame (RWD Life Science Inc., China)

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Unlike ACD affecting other body sites, CHE poses unique challenges because the hands are constantly in use for occupational tasks and daily activities

This size-based penetration advantage is central to its topical research applications and helps explain why laboratory studies have consistently demonstrated biological activity following topical application models

It also provides excellent skin whitening and anti-aging treatment