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When your levels of estrogen, testosterone, and progesterone are out of balance, it can affect a range of bodily processes, including your mental health and sleep quality

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doi:10.1001/jamanetworkopen.2024.57349 2026 The Author(s)

Metabolic abnormalities directly drive vascular remodeling through energy metabolic reprogramming, substrate competition, and signaling pathway activation, while the process of vascular remodeling further exacerbates metabolic imbalance, forming a pathological cascade reaction