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In vivo , knockdown of LPCAT3 aggravates OA progression and inflammation, while pharmacological inhibition of ACSL4 partially rescues these effects (76)

however, clinical trials are currently lacking (Schepici et al., 2020

MPNSTs are usually composed of relatively uniform spindled cells arranged in densely cellular fascicles and/or whorls (fibrosarcoma-like appearance), often alternating and interdigitating with more hypocellular and myxoid areas (marble-like appearance) (Figure 22)

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The binding of BECN1 to SLC7A11, a core component of xCT, inhibits the xCT function and promotes ferroptosis [62] , indicating that BECN1 is a key ferroptosis inducer [63]