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The methyl group at the 1-position of the indazole was particularly important for pharmacokinetic properties, contributing to the extended half-life that enables once-daily dosing

A positive outcome would reshape the narrative and potentially reignite interest in GLP-1 RAs across neurodegenerative disorders

For the Bradford assay, 250 mg of the treated and control helminth tissues were homogenized using 500 l of RIPA buffer (Radioimmunoprecipitation assay)

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