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44 Although the cells at the base are smaller, they show atypical features including conspicuous nucleolation, nuclear membrane irregularity, hyperchromasia, increased nuclear-to-cytoplasmic ratios, and mitotic activity, all of which are unusual in the banal common acquired nevus (Figures 14 and 15)

Comment: Several commenters did not support the proposal to include the NPI in the MRF

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Another approach would have been to conduct a pair-feeding study, but this was not done because it was not possible to make all feeding conditions exactly the same