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Protein kinase C type isoform 2 (PKCII) is able to recognize the initial lipid peroxidation, promote the phosphorylation of ACSL4 on Thr328 to activate phospho-ACSL4, and facilitate the incorporation of PUFA into PLs, leading to the termination of the cells ( According to recent findings, membrane lipids are key regulators of ferroptosis

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This dose allows the prescribing healthcare provider to check for any side effects before increasing the dose to the next level (7.5mg/37.5mg)