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When the COX2 inhibition values were analyzed, IC 50 values in the range of 0.040.14 M were found, being comparable to celocoxib (0.05 M), where 20 , 24 , and 25 were more potent than the drug itself, used as a standard

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Accordingly, monitoring of total concentrations may be misleading since free concentrations may be substantially elevated in patients with hepatic disease whereas total concentrations may appear to be normal [seeBoxed Warning,Contraindications (4), andWarnings and Precautions (5.1)]

When oxidative stress is high, more GSH converts to GSSG