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the first amino acid differs

However, years later in 2016, a pharmacological analysis of this ligand demonstrated interspecies differences between the rodent and human GIP system and also led to the conclusion that the human Pro3(GIP) was a potent partial agonist with the ability to activate the human GIP receptor with a maximal efficiency (E max ) of 90% compared to human GIP (68)

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These are self-reported, so they come with obvious limits (no control group, selection bias), but they help explain interest in daily use among health-focused individuals

doi: 10.1146/annurev.nutr.18.1.39