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10.1016/j.exphem.2010.10.006 28 LinY

Alternatively, seleno-GPxs may play an important role in mitigating some of the side effects (specifically inflammatory response) of radiotherapy which are driven by peroxides-activated signaling pathways

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This interplay between iron metabolism and hypoxia is particularly significant in the context of CSCs, which reside in hypoxic niches [91] and leverage these adaptive responses to sustain their stemness properties and resistance to therapeutics (reviewed [92])

Caravagna, C