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Getting the baseline right matters more than most people realize

Sandson: Usually not, unless the single pathway thats inhibited is the major one

204 The accumulation of the hyperphosphorylated tau protein, a type of microtubule-associated protein (MAP), induces the formation of neurofibrillary tangles, and the aggregation of the amyloid-beta 1-42 (A42) fragment produced from APP results in the formation of senile plaques by disturbing the activity of PS1 and PS2