[1] [2] This triple-receptor mechanism distinguishes it from currently approved agents such as semaglutide (a GLP-1 agonist) or tirzepatide (a dual GIP/GLP-1 agonist)
You can take estrogen orally with pills or get it through the skin (aka transdermally) with patches, creams, gels, and sprays
Avoid standard capsules that may be destroyed by stomach acid
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The combination of skin-lightening agents with vitamins and UV filters has also been shown to improve skin hyperpigmentation [52], as shown in a study on melasma treatment comparing a cream containing 4% hydroquinone, 10% buffered glycolic acid, vitamins C and E, and UV filters with a UV-only sunscreen [202]