Results were presented at the ADA 86th Scientific Sessions on June 6, 2026: retatrutide 12mg reduced the apnea-hypopnea index (AHI) by 60.6% from a severe-OSA baseline of 58.6 events per hour to roughly 22.5 events per hour (moderate OSA range)
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What is Semaglutide/GLP-1
This could result in an accidental overdose or severe side effects
Key timing considerations: Side effect profile tends to be somewhat milder than semaglutide, which may reduce the importance of sleep-through timing Same 48-hour minimum spacing rule applies if changing injection days Pre-filled pen format means no reconstitution time, making spontaneous timing adjustments easier Many dulaglutide users report minimal side effects after the first month, at which point timing becomes purely a convenience decision Retatrutide (weekly injectable, investigational) Dosing frequency: Once weekly Half-life: Data from Phase 2 trials suggest approximately 6 days Peak concentration: Approximately 24 to 72 hours after injection Recommended timing approach: As a triple agonist (GLP-1/GIP/glucagon), retatrutide may produce a different side effect profile than pure GLP-1 or dual GLP-1/GIP agonists
