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Furthermore, NAD levels in the brain are essential for maintaining central nervous system (CNS) vascular integrity, due to NAD maintaining an energy supply that plays crucial roles in cell survival, such as having a protective factor in cerebral ischemia, since its disorder leads to energy depletion (13, 52)

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Clinical studies with LH-RH antagonists in men with prostate cancer Clinical trials showed persistent inhibition of testosterone levels in patients with advanced (stage C and D2) prostatic cancer treated bid s.c