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Other risk factors include certain gastrointestinal conditions, autoimmune conditions such as pernicious anaemia, long-term use of some medications, and increasing age

Heritable mutations in neurofilaments can cause several neurological diseases including Giant Axonal Neuropathy, CharcotMarieTooth (CMT) disease, Amyotrophic Lateral Sclerosis (ALS), and Parkinsons disease (PD) 57

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These include hydroxylases, transferases like Cu/Zn superoxide dismutase, cytochrome c oxidase, hephaestin, ferroxidase, ceruloplasmin, monoamine oxidase, lysyl oxidase, and dopamine -monooxygenase, which catalyzes the conversion of dopamine to epinephrine [27]