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All experiments received specific approval from the local Ethics Committee at the School of Medicine (the University of Zagreb, Zagreb, Croatia)

Several meta-analyses of observational studies have found elevated blood concentrations of homocysteine to be linked with an increased risk of dementia (74) or Alzheimers disease (68, 75-78)

This is used to generate a health state profile ranging from 20% improvement at week 52/40, previously identified as the MCID in patients with PsA