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[24] [25] NAD+ depletion through disruption of mitochondrial homeostasis is a substantial contributor to the metabolic dysfunction in WS, according to a 2019 study

Vilarrasa et al

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Together with riboflavin and other micronutrients, the NAD and NADP coenzymes work to convert fats and proteins to glucose and assist in the oxidation of glucose

Most people start noticing subtle changes like improved sleep or recovery within 1 to 2 weeks