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In L-cells of the lower intestine and colon the proprotein convertase subtilisin/kexin type 1 (or PCSK1/PC1) cleaves after single or double basic amino acids to liberate glicentin (amino acids 21-89 in proglucagon), oxyntomodulin (amino acids 53-89 in proglucagon), GLP-1 (amino acids 92-128 in proglucagon), and GLP-2 (amino acids 146-178 in proglucagon) (see UniProt P01275)

The peptide has attracted scientific interest due to its unique structure and its long-standing presence within neuropeptide-related research literature

As presented in Figure 2, the magnitude of ROS production in melanocytes in vitiligo patients is due to a high electrical potential in mitochondrial intermembrane space (Schlame and Greenberg, 2017)

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