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DECREASED GH IN NORMAL AGING: SIMILARITIES WITH AND DIFFERENCES FROM ADULT GROWTH HORMONE DEFICIENCY While not identical to aging, adult growth hormone deficiency (AGHD) provides the most comprehensive data on reduced GH secretion, treatment effects, adult dosing strategies, and the safety and side effects of GH replacement

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Of particular relevance to IGF-1 anabolic research are TSC2 (relieving inhibition of mTORC1, driving protein synthesis) and FoxO transcription factors (inhibiting their nuclear translocation, blocking expression of atrogenes like MuRF1 and atrogin-1 that drive muscle protein breakdown)