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Importantly, this proof-of-concept study showed that the relative abundance of Lactobacillus , a genus associated with weight loss 58 , was uniquely increased and Erysipelatoclostridium was distinctly decreased in mice given 5A-1MQ treatment and an LD switch compared to mice switched to LD and given vehicle treatment

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The peer-reviewed literature is also concentrated within a single research group (Watowich lab, University of Texas at Austin) and its industry partner Ridgeline Therapeutics, with limited independent replication to date

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