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However, about 10-15% of acetaminophen is metabolized by CYP2E1 into a toxic metabolite known as NAPQI (N-acetyl-p-benzoquinone imine).[ref] Detoxification with glutathione: NAPQI then needs to be neutralized with glutathione, which is catalyzed using the GST genes

(4) Research has demonstrated that the N-terminal tripeptide of IGF-1 is critical for high-affinity IGFBP binding, and its removal substantially reduces sequestration by these regulatory proteins