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Pull the plunger back to draw in an amount of air equal to the volume of liquid you plan to withdraw (e.g., pull in 2mL of air if you're going to draw 2mL of water)

Pastor-Maldonado, C.J., et al

Additionally, if you are using insulin or sulfonylureas, the risk of hypoglycaemia may increase when starting tirzepatide, so discuss potential dose adjustments with your diabetes team

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Moreover, studies using mouse genetics have identified the importance of endothelial cell DPP-4 in the physiological control of glucose homeostasis and as a key cellular target for the pharmacological glucoregulatory response to DPP-4 inhibition (20)