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Biotin injections can help raise low biotin levels relatively quickly, because the vitamin is delivered directly into the bloodstream (bypassing the digestive system)

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Phosphatidylserine aminotransferase 1 (PSAT1) and phosphatidylserine phosphohydrolase (PSPH) have been identified as key mediators of one-carbon metabolism

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This rise is linked to early neurological impairment and might potentially result in hemorrhagic transformation and severe brain oedema following tPA thrombolysis (Liu, 2021)