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AASLD 2017 Current Status of Pharmacologic Treatments for NASH No approved therapies for NASH Currently available therapeutics with (some) proven efficacy Vitamin E Pioglitazone NASH: targets for therapeutics Endpoints for clinical trials Disease Activity (steatohepatitis) = NAFLD Activity Score (NAS) Disease Progression = Fibrosis Stage Clinical outcomes : Cirrhosis (MELD, Portal hypertension), Liver-related outcome, death Adapted from Konerman MA