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SAM is the universal methyl donor for DNA methylation

Evidence-based autoimmune disease treatments include disease-modifying antirheumatic drugs (DMARDs) like methotrexate, biologic agents targeting specific inflammatory pathways (TNF- inhibitors, IL-6 inhibitors), JAK inhibitors, corticosteroids for acute flares, and immunomodulators

Most patients begin experiencing initial improvements in sleep and energy within the first month, with significant body composition changes becoming evident after three to six months of consistent therapy under medical supervision