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pylori , the reductive activation probably requires oxygen-insensitive NADPH nitroreductases, including RdxA (mutations are most commonly associated with metronidazole resistance) and FrxA 18,19,20

Empty pACAd5-IRES-GFP vector was utilized as the control

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Glutathione S -transferase Glutathione S -transferases ( GSTs ), previously known as ligandins , are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification