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Animal model measurements All animal experiments were carried out according to the University of Ottawa animal care ethics and guidelines (protocol# HS2923)

Ghrelin null mice show an increased utilization of fat as an energy substrate when placed on a high-fat diet, which may indicate that ghrelin is involved in modulating the use of metabolic substrates (349)

Deformability Optimization: Integrating biocompatible edge activators to lower the elastic modulus of the membrane, enabling the vesicles to physically squeeze through the stratum corneum via intercellular pathways

Section 503A pharmacies generally require a patient-specific prescription, are overseen mainly by state pharmacy boards, and face limits on interstate distribution and on mass-producing copies of commercial drugs

Step-by-step reconstitution for GHK-Cu: Allow the sealed vial to equilibrate to room temperature for approximately 1520 minutes before opening (minimizes condensation inside the vial)