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This review puts forward the plausible glucose-lowering mechanism of dopamine receptor agonists, however more studies are needed to clarify the specific actions of central dopamine and prolactin and dopaminergic signaling in insulin-sensitive tissues which would identify potential therapeutic strategies for the treatment of metabolic disorders including type 2 diabetes and metabolic syndrome and even Parkinsons disease

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AMPK signaling decreases the transcription of lipogenic genes by phosphorylation of transcription factors SREBP1 and carbohydrate-responsive element binding protein, which control the expression of fatty acid biosynthetic genes (55, 56)

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